Manganese Exposure Aggravates β-Amyloid Pathology by Microglial Activation

Manganese Exposure Aggravates β-Amyloid Pathology by Microglial Activation

Human epidemiological evidence and animal experimental data suggest that chronic manganese (Mn) exposure increases the risk of Alzheimer’s disease (AD) and amyloid plaques, a hallmark of AD brain pathology, but the underlying mechanisms were not fully understood. Using the transgenic APP/PS1/Tau tri...

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Bibliographic Details
Main Authors: Geng Lin, Xinlu Li, Xiaofeng Cheng, Ning Zhao, Wei Zheng
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-11-01
Series:Frontiers in Aging Neuroscience
Subjects:
Alzheimer’s disease
β-amyloid
microglia
manganese
neuroinflammation
cytokines
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2020.556008/full

Internet

https://www.frontiersin.org/articles/10.3389/fnagi.2020.556008/full

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