WNT Activation and TGFβ-Smad Inhibition Potentiate Stemness of Mammalian Auditory Neuroprogenitors for High-Throughput Generation of Functional Auditory Neurons In Vitro

WNT Activation and TGFβ-Smad Inhibition Potentiate Stemness of Mammalian Auditory Neuroprogenitors for High-Throughput Generation of Functional Auditory Neurons In Vitro

Hearing loss affects over 460 million people worldwide and is a major socioeconomic burden. Both genetic and environmental factors (i.e., noise overexposure, ototoxic drug treatment and ageing), promote the irreversible degeneration of cochlear hair cells and associated auditory neurons, leading to...

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Bibliographic Details
Main Authors: Francis Rousset, Giulia Schilardi, Stéphanie Sgroi, German Nacher-Soler, Rebecca Sipione, Sonja Kleinlogel, Pascal Senn
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Cells
Subjects:
otic progenitors
auditory neuroprogenitors
auditory neurons
auditory progenitors stemness
auditory neuron regeneration
in vitro model
Online Access:https://www.mdpi.com/2073-4409/11/15/2431

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https://www.mdpi.com/2073-4409/11/15/2431

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