Validation of Vancomycin Area under the Concentration—Time Curve Estimation by the Bayesian Approach Using One-Point Samples for Predicting Clinical Outcomes in Patients with Methicillin-Resistant <i>Staphylococcus aureus</i> Infections

Validation of Vancomycin Area under the Concentration—Time Curve Estimation by the Bayesian Approach Using One-Point Samples for Predicting Clinical Outcomes in Patients with Methicillin-Resistant <i>Staphylococcus aureus</i> Infections

Area under the concentration–time curve (AUC)-guided vancomycin treatment is associated with decreased nephrotoxicity. It is preferable to obtain two samples to estimate the AUC. This study examined the usefulness of AUC estimation via trough concentration (C<sub>min</sub>)-only sampling...

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Bibliographic Details
Main Authors: Takashi Ueda, Yoshio Takesue, Kazuhiko Nakajima, Kaoru Ichiki, Kaori Ishikawa, Kumiko Yamada, Toshie Tsuchida, Naruhito Otani, Yoshiko Takahashi, Mika Ishihara, Shingo Takubo, Hiroki Ikeuchi, Motoi Uchino, Toshimi Kimura, Kazuaki Matsumoto, Kazutaka Oda, Takeshi Kimura
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:Antibiotics
Subjects:
vancomycin
area under the concentration–time curve
Bayesian estimation
methicillin-resistant <i>Staphylococcus aureus</i> infection
nephrotoxicity
Online Access:https://www.mdpi.com/2079-6382/11/1/96

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https://www.mdpi.com/2079-6382/11/1/96

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