Pharmacological NF‐κB inhibition decreases cisplatin chemoresistance in muscle‐invasive bladder cancer and reduces cisplatin‐induced toxicities.

Pharmacological NF‐κB inhibition decreases cisplatin chemoresistance in muscle‐invasive bladder cancer and reduces cisplatin‐induced toxicities.

Most patients with muscle‐invasive bladder cancer (MIBC) are not cured with platinum chemotherapy. Up‐regulation of nuclear factor kappa light‐chain enhancer of activated B cells (NF‐κB) is a major mechanism underlying chemoresistance, suggesting that its pharmacological inhibition may increase plat...

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Bibliographic Details
Main Authors: Rui M. Gil da Costa, Christine Levesque, Daniella Bianchi‐Frias, Payel Chatterjee, Hung‐Ming Lam, Carlos Santos, Ilsa M. Coleman, Pedro Ferreirinha, Manuel Vilanova, Nazaré Pinto da Cunha, Hugo Carvalho, Alexandra Moreira‐Pais, Ana Faustino‐Rocha, Tiago Neto, José Batista da Costa, Jonathan L. Wright, Rita Ferreira, Paula A. Oliveira, Joaquim Mendes, Margarida M. S. M. Bastos, Bruno Colaço, Carlos Lopes, Peter C. Black, Christopher J. Sweeney, Peter S. Nelson
Format: Article
Language:English
Published: Wiley 2023-12-01
Series:Molecular Oncology
Subjects:
chemoresistance
cisplatin
muscle wasting
nephrotoxicity
parthenolide
Online Access:https://doi.org/10.1002/1878-0261.13504

Internet

https://doi.org/10.1002/1878-0261.13504

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