Early⁃onset Alzheimer's disease caused by PSEN1 gene mutation: two cases reports and literature review

Early⁃onset Alzheimer's disease caused by PSEN1 gene mutation: two cases reports and literature review

Objective To report 2 pedigrees of early⁃onset familial Alzheimer's disease (EOFAD) caused by PSEN1 gene mutation, review previous studies and summarize the PSEN1 gene mutation sites, clinical presentation and genotype characteristics of EOFAD in China. Methods and Results The clinical data of...

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Bibliographic Details
Main Authors: ZHANG Yuan, SUN Meng⁃fan, JIA Zi⁃yan, JIANG Ji⁃wei, WANG Yan⁃li, XU Jun
Format: Article
Language:English
Published: Tianjin Huanhu Hospital 2021-11-01
Series:Chinese Journal of Contemporary Neurology and Neurosurgery
Subjects:
alzheimer disease
presenilin⁃1
genes
mutation
pedigree
Online Access:http://www.cjcnn.org/index.php/cjcnn/article/view/2420

Internet

http://www.cjcnn.org/index.php/cjcnn/article/view/2420

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