Propranolol-Loaded Limonene-Based Microemulsion Thermo-Responsive Mucoadhesive Nasal Nanogel: Design, In Vitro Assessment, Ex Vivo Permeation, and Brain Biodistribution

Propranolol-Loaded Limonene-Based Microemulsion Thermo-Responsive Mucoadhesive Nasal Nanogel: Design, In Vitro Assessment, Ex Vivo Permeation, and Brain Biodistribution

Propranolol is the first-line drug for managing migraine attacks. D-limonene is a citrus oil known for its neuroprotective mechanism. Thus, the current work aims to design a thermo-responsive intranasal limonene-based microemulsion mucoadhesive nanogel to improve propranolol efficacy. Microemulsion...

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Bibliographic Details
Main Authors: Kawthar K. Abla, Souraya Domiati, Rania El Majzoub, Mohammed M. Mehanna
Format: Article
Language:English
Published: MDPI AG 2023-06-01
Series:Gels
Subjects:
brain distribution
BBB
limonene
microemulsion
thermo-sensitive
mucoadhesion
Online Access:https://www.mdpi.com/2310-2861/9/6/491

Internet

https://www.mdpi.com/2310-2861/9/6/491

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