Upstream Stimulatory Factors Regulate HIV-1 Latency and Are Required for Robust T Cell Activation

HIV-1 provirus expression is controlled by signaling pathways that are responsive to T cell receptor engagement, including those involving Ras and downstream protein kinases. The induction of transcription from the HIV-1 LTR in response to Ras signaling requires binding of the Ras-responsive element...

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Bibliographic Details
Main Authors: Riley M. Horvath, Ivan Sadowski
Format: Article
Language:English
Published: MDPI AG 2023-06-01
Series:Viruses
Subjects:
Online Access:https://www.mdpi.com/1999-4915/15/7/1470