Du Huo Ji Sheng Tang inhibits Notch1 signaling and subsequent NLRP3 activation to alleviate cartilage degradation in KOA mice

Abstract Background Knee osteoarthritis (KOA) has a complex pathological mechanism and is difficult to cure. The traditional medicine Du Huo Ji Sheng Tang (DHJST) has been used for the treatment of KOA for more than one thousand years, but its mechanism for treating KOA has not been revealed. In our...

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Bibliographic Details
Main Authors: Wen-jin Chen, Yin Zhuang, Wei Peng, Wei Cui, Shu-jun Zhang, Jian-wei Wang
Format: Article
Language:English
Published: BMC 2023-06-01
Series:Chinese Medicine
Subjects:
Online Access:https://doi.org/10.1186/s13020-023-00784-y