Pharmacophore mapping: Prediction of BCR–ABL kinase inhibitory activity of α-benzylthio chalcones
In this investigation, 3D pharmacophore modeling studies were performed on a diverse set of 33 α-benzylthio chalcone derivatives that demonstrate anticancer activity by blocking BCR–ABL phosphorylation in leukemic cells. Pharmacophore modeling is based on the principle of the alignment of pharmacoph...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Faculty of Pharmacy, Cairo University
2014-06-01
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| Series: | Bulletin of Faculty of Pharmacy Cairo University |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1110093113000367 |