Blood–brain barrier breakdown, central nervous system cell damage, and infiltrated T cells as major adverse effects in CAR-T-related deaths: a literature review

Blood–brain barrier breakdown, central nervous system cell damage, and infiltrated T cells as major adverse effects in CAR-T-related deaths: a literature review

BackgroundCAR-T-related deaths observed worldwide are rare. The underlying pathogenetic mechanisms are the subject of study, as are the findings that enable diagnosis. A systematic literature search of the PubMed database and a critical review of the collected studies were conducted from the incepti...

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Bibliographic Details
Main Authors: Fabio Del Duca, Gabriele Napoletano, Gianpietro Volonnino, Aniello Maiese, Raffaele La Russa, Marco Di Paolo, Serena De Matteis, Paola Frati, Massimiliano Bonafè, Vittorio Fineschi
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-01-01
Series:Frontiers in Medicine
Subjects:
CAR-T
death
edema
blood–brain barrier breakdown
autopsy
Online Access:https://www.frontiersin.org/articles/10.3389/fmed.2023.1272291/full

Internet

https://www.frontiersin.org/articles/10.3389/fmed.2023.1272291/full

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