Origin of Elevated S-Glutathionylated GAPDH in Chronic Neurodegenerative Diseases

Origin of Elevated S-Glutathionylated GAPDH in Chronic Neurodegenerative Diseases

H<sub>2</sub>O<sub>2</sub>-oxidized glyceraldehyde-3-phosphate dehydrogenase (GAPDH) catalytic cysteine residues (C<i><sub>c</sub></i>(SH) undergo rapid S-glutathionylation. Restoration of the enzyme activity is accomplished by thiol/disulfide S<sub...

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Bibliographic Details
Main Authors: Paul A. Hyslop, Leonard N. Boggs, Michael O. Chaney
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:International Journal of Molecular Sciences
Subjects:
glutathione
oxidative stress
redox signaling
glyceraldehyde-3-phosphate dehydrogenase
hydrogen peroxide
neurodegenerative disease
Online Access:https://www.mdpi.com/1422-0067/24/6/5529

Internet

https://www.mdpi.com/1422-0067/24/6/5529

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