Key role of the CCR2-CCL2 axis in disease modification in a mouse model of tauopathy

Key role of the CCR2-CCL2 axis in disease modification in a mouse model of tauopathy

Abstract Background For decades, dementia has been characterized by accumulation of waste in the brain and low-grade inflammation. Over the years, emerging studies highlighted the involvement of the immune system in neurodegenerative disease emergence and severity. Numerous studies in animal models...

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Bibliographic Details
Main Authors: Hila Ben-Yehuda, Michal Arad, Javier María Peralta Ramos, Efrat Sharon, Giulia Castellani, Shir Ferrera, Liora Cahalon, Sarah Phoebeluc Colaiuta, Tomer-Meir Salame, Michal Schwartz
Format: Article
Language:English
Published: BMC 2021-06-01
Series:Molecular Neurodegeneration
Subjects:
Tauopathy
Immunotherapy
CCR2
CCL2
Monocytes
Regulatory T cells
Online Access:https://doi.org/10.1186/s13024-021-00458-z

Internet

https://doi.org/10.1186/s13024-021-00458-z

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