Application of Force to a Syndecan-4 Containing Complex With Thy-1–αVβ3 Integrin Accelerates Neurite Retraction

Application of Force to a Syndecan-4 Containing Complex With Thy-1–αVβ3 Integrin Accelerates Neurite Retraction

Inflammation contributes to the genesis and progression of chronic diseases, such as cancer and neurodegeneration. Upregulation of integrins in astrocytes during inflammation induces neurite retraction by binding to the neuronal protein Thy-1, also known as CD90. Additionally, Thy-1 alters astrocyte...

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Bibliographic Details
Main Authors: Francesca Burgos-Bravo, Samuel Martínez-Meza, Andrew F. G. Quest, Christian A. M. Wilson, Lisette Leyton
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Molecular Biosciences
Subjects:
cell–cell adhesion
single-molecule analysis
trimolecular adhesion complex
mechano-sensor
mechano-transduction
inflammation
Online Access:https://www.frontiersin.org/article/10.3389/fmolb.2020.582257/full

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https://www.frontiersin.org/article/10.3389/fmolb.2020.582257/full

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