Proposal of a functional prognostic scale in mexican patients with Guillain-Barré syndrome
Background: There is currently no prognostic scale for patients with Guillain-Barré syndrome (GBS) in the Mexican population. Objective: The objective of the study was to examine the factors associated with functional prognosis by proposing short-term and long-term prognostic scales. Methods: Prospe...
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Permanyer
2024-01-01
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| Series: | Revista de Investigación Clínica |
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| Online Access: | https://www.clinicalandtranslationalinvestigation.com/frame_esp.php?id=514 |
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| author | Edwin S. Vargas-Cañas Juan C. López-Hernández Sandra Badial-Ochoa Javier Galnares-Olalde Victoria Martínez-Angeles Elliot Hernández-Angelino David Domínguez-Romero Raúl Medina-Rioja |
| author_facet | Edwin S. Vargas-Cañas Juan C. López-Hernández Sandra Badial-Ochoa Javier Galnares-Olalde Victoria Martínez-Angeles Elliot Hernández-Angelino David Domínguez-Romero Raúl Medina-Rioja |
| author_sort | Edwin S. Vargas-Cañas |
| collection | DOAJ |
| description | Background: There is currently no prognostic scale for patients with Guillain-Barré syndrome (GBS) in the Mexican population. Objective: The objective of the study was to examine the factors associated with functional prognosis by proposing short-term and long-term prognostic scales. Methods: Prospective cohort of patients with GBS at an academic medical center, with neuroconduction study and 6-month follow-up. Through logistic regression, we evaluated clinical and paraclinical variables,\\r\\nand the results are expressed as odds ratios 95% confidence intervals [CIs]). We used a scale to predict poor functional prognosis. The performance of the scale was assessed using the area under the curve (AUC). Results: A total of 259 patients (age 46.1 +- 16.1 years) were included in the study; 38.6% had a history of diarrhea, and 42.8% had an axonal variant. The rates of poor functional prognosis were 36.6% and 22.7% at 3 and 6 months of follow-up, respectively. The following variables were included in the univariate logistic regression: age >- 70 years, history of diarrhea, axonal variant, and Medical Research Council score. We performed a prognostic scale (0-9 points), with AUC of 0.81 (95% CI: 0.75-0.86) at 3 months, and 0.82 (95% CI: 0.76-0.87) at 6 months, which was higher than the modified Erasmus Guillain-Barré Outcome Score scale at admission (AUC: 0.75. 95% CI: 0.69-0.81 and AUC: 0.78. 95% CI: 0.72-0.83). Conclusion: The proposed prognostic scale performs well in discerning poor functional prognosis in short- and long-term frames among Mexican patients.
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| first_indexed | 2025-02-17T10:33:56Z |
| format | Article |
| id | doaj.art-c68409c287694037b1e36012640fa4e4 |
| institution | Directory Open Access Journal |
| issn | 0034-8376 2564-8896 |
| language | English |
| last_indexed | 2025-02-17T10:33:56Z |
| publishDate | 2024-01-01 |
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| series | Revista de Investigación Clínica |
| spelling | doaj.art-c68409c287694037b1e36012640fa4e42024-12-30T21:20:26ZengPermanyerRevista de Investigación Clínica0034-83762564-88962024-01-0176610.24875/RIC.24000149Proposal of a functional prognostic scale in mexican patients with Guillain-Barré syndromeEdwin S. Vargas-Cañas0Juan C. López-Hernández1Sandra Badial-Ochoa2Javier Galnares-Olalde3Victoria Martínez-Angeles4Elliot Hernández-Angelino5David Domínguez-Romero6Raúl Medina-Rioja7Neuromuscular Diseases Clinic, Instituto Nacional de Neurología y Neurocirugía "Dr. Manuel Velasco Suárez", Mexico City, MexicoNeuromuscular Diseases Department, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, Mexico City, MexicoNeuromuscular Diseases Clinic, Instituto Nacional de Neurología y Neurocirugía "Dr. Manuel Velasco Suárez", Mexico City, MexicoNeuromuscular Diseases Clinic, Instituto Nacional de Neurología y Neurocirugía "Dr. Manuel Velasco Suárez", Mexico City, MexicoDepartment of Neuropsychiatry, Instituto Nacional de Neurología y Neurocirugía "Dr. Manuel Velasco Suárez", Mexico City, MexicoEmergency Department, Instituto Nacional de Neurología y Neurocirugía "Dr. Manuel Velasco Suárez", Mexico City, MexicoEmergency Department, Instituto Nacional de Neurología y Neurocirugía "Dr. Manuel Velasco Suárez", Mexico City, MexicoEmergency Department, Instituto Nacional de Neurología y Neurocirugía "Dr. Manuel Velasco Suárez", Mexico City, MexicoBackground: There is currently no prognostic scale for patients with Guillain-Barré syndrome (GBS) in the Mexican population. Objective: The objective of the study was to examine the factors associated with functional prognosis by proposing short-term and long-term prognostic scales. Methods: Prospective cohort of patients with GBS at an academic medical center, with neuroconduction study and 6-month follow-up. Through logistic regression, we evaluated clinical and paraclinical variables,\\r\\nand the results are expressed as odds ratios 95% confidence intervals [CIs]). We used a scale to predict poor functional prognosis. The performance of the scale was assessed using the area under the curve (AUC). Results: A total of 259 patients (age 46.1 +- 16.1 years) were included in the study; 38.6% had a history of diarrhea, and 42.8% had an axonal variant. The rates of poor functional prognosis were 36.6% and 22.7% at 3 and 6 months of follow-up, respectively. The following variables were included in the univariate logistic regression: age >- 70 years, history of diarrhea, axonal variant, and Medical Research Council score. We performed a prognostic scale (0-9 points), with AUC of 0.81 (95% CI: 0.75-0.86) at 3 months, and 0.82 (95% CI: 0.76-0.87) at 6 months, which was higher than the modified Erasmus Guillain-Barré Outcome Score scale at admission (AUC: 0.75. 95% CI: 0.69-0.81 and AUC: 0.78. 95% CI: 0.72-0.83). Conclusion: The proposed prognostic scale performs well in discerning poor functional prognosis in short- and long-term frames among Mexican patients. https://www.clinicalandtranslationalinvestigation.com/frame_esp.php?id=514Guillain-Barré syndrome. Prognostic scale. Prognostic. Mexican patients. |
| spellingShingle | Edwin S. Vargas-Cañas Juan C. López-Hernández Sandra Badial-Ochoa Javier Galnares-Olalde Victoria Martínez-Angeles Elliot Hernández-Angelino David Domínguez-Romero Raúl Medina-Rioja Proposal of a functional prognostic scale in mexican patients with Guillain-Barré syndrome Revista de Investigación Clínica Guillain-Barré syndrome. Prognostic scale. Prognostic. Mexican patients. |
| title | Proposal of a functional prognostic scale in mexican patients with Guillain-Barré syndrome |
| title_full | Proposal of a functional prognostic scale in mexican patients with Guillain-Barré syndrome |
| title_fullStr | Proposal of a functional prognostic scale in mexican patients with Guillain-Barré syndrome |
| title_full_unstemmed | Proposal of a functional prognostic scale in mexican patients with Guillain-Barré syndrome |
| title_short | Proposal of a functional prognostic scale in mexican patients with Guillain-Barré syndrome |
| title_sort | proposal of a functional prognostic scale in mexican patients with guillain barre syndrome |
| topic | Guillain-Barré syndrome. Prognostic scale. Prognostic. Mexican patients. |
| url | https://www.clinicalandtranslationalinvestigation.com/frame_esp.php?id=514 |
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