CDK6-PI3K signaling axis is an efficient target for attenuating ABCB1/P-gp mediated multi-drug resistance (MDR) in cancer cells

CDK6-PI3K signaling axis is an efficient target for attenuating ABCB1/P-gp mediated multi-drug resistance (MDR) in cancer cells

Abstract Background Multidrug resistance (MDR) mediated by ATP binding cassette subfamily B member 1 (ABCB1/P-gp) is a major cause of cancer chemotherapy failure, but the regulation mechanisms are largely unknown. Methods Based on single gene knockout, we studied the regulation of CDK6-PI3K axis on...

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Bibliographic Details
Main Authors: Lei Zhang, Yidong Li, Chaohua Hu, Yangmin Chen, Zhuo Chen, Zhe-Sheng Chen, Jian-Ye Zhang, Shuo Fang
Format: Article
Language:English
Published: BMC 2022-04-01
Series:Molecular Cancer
Subjects:
Multidrug resistance (MDR)
cancer
Transcriptome sequencing
Cyclin dependent kinase 6 (CDK6)
PI3K 110α/110β
Signaling axis
Online Access:https://doi.org/10.1186/s12943-022-01524-w

Internet

https://doi.org/10.1186/s12943-022-01524-w

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