Application of Amplicon-Based Targeted NGS Technology for Diagnosis of Drug-Resistant Tuberculosis Using FFPE Specimens

Application of Amplicon-Based Targeted NGS Technology for Diagnosis of Drug-Resistant Tuberculosis Using FFPE Specimens

ABSTRACT Next-generation sequencing (NGS) enables rapid identification of common and rare drug-resistant genetic variations from tuberculosis (TB) patients’ sputum samples and MTB isolates. However, whether this technology is effective for formalin-fixed and paraffin-embedded (FFPE) tissues remains...

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Bibliographic Details
Main Authors: Jing Song, Weili Du, Zichen Liu, Jialu Che, Kun Li, Nanying Che
Format: Article
Language:English
Published: American Society for Microbiology 2022-02-01
Series:Microbiology Spectrum
Subjects:
amplicon-based targeted NGS
tuberculosis
drug resistant mutations
FFPE tissue samples
Online Access:https://journals.asm.org/doi/10.1128/spectrum.01358-21

Internet

https://journals.asm.org/doi/10.1128/spectrum.01358-21

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