Methylglyoxal Impairs Sister Chromatid Separation in Lymphocytes

Methylglyoxal Impairs Sister Chromatid Separation in Lymphocytes

The accurate segregation of sister chromatids is complex, and errors that arise throughout this process can drive chromosomal instability and tumorigenesis. We recently showed that methylglyoxal (MGO), a glycolytic by-product, can cause chromosome missegregation events in lymphocytes. However, the u...

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Bibliographic Details
Main Authors: Leigh Donnellan, Clifford Young, Bradley S. Simpson, Varinderpal S. Dhillon, Maurizio Costabile, Peter Hoffmann, Michael Fenech, Permal Deo
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:International Journal of Molecular Sciences
Subjects:
methylglyoxal
chromosomal instability
sister chromatid separation
proteomics
Online Access:https://www.mdpi.com/1422-0067/23/8/4139

Internet

https://www.mdpi.com/1422-0067/23/8/4139

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