Methylglyoxal Impairs Sister Chromatid Separation in Lymphocytes

Methylglyoxal Impairs Sister Chromatid Separation in Lymphocytes

The accurate segregation of sister chromatids is complex, and errors that arise throughout this process can drive chromosomal instability and tumorigenesis. We recently showed that methylglyoxal (MGO), a glycolytic by-product, can cause chromosome missegregation events in lymphocytes. However, the u...

Full description

Bibliographic Details
Main Authors:	Leigh Donnellan, Clifford Young, Bradley S. Simpson, Varinderpal S. Dhillon, Maurizio Costabile, Peter Hoffmann, Michael Fenech, Permal Deo
Format:	Article
Language:	English
Published:	MDPI AG 2022-04-01
Series:	International Journal of Molecular Sciences
Subjects:	methylglyoxal chromosomal instability sister chromatid separation proteomics
Online Access:	https://www.mdpi.com/1422-0067/23/8/4139

Similar Items

SISTER CHROMATID EXCHANGES IN RIVER BUFFALO FEMALES WITH CHROMOSOMAL FRAGILITY
by: IOANA NICOLAE, et al.
Published: (2023-10-01)

"Sister Chromatid Exchanges and Micronuclei in Lymphocyte of Nurses Handling Antineoplastic Drugs"
by: M Ansari-Lari, et al.
Published: (2001-06-01)

"Sister Chromatid Exchanges and Micronuclei in Lymphocyte of Nurses Handling Antineoplastic Drugs"
by: M Ansari-Lari, et al.
Published: (2001-07-01)

Mechanics of Sister Chromatids studied with a Polymer Model
by: Yang eZhang, et al.
Published: (2013-10-01)

Study of the Effect of MMC on the Sister Chromatid Exchange in the Human Lymphocytes
by: S ِAkbari-Kamranvar, et al.
Published: (2004-03-01)

Proteomic Analysis of Methylglyoxal Modifications Reveals Susceptibility of Glycolytic Enzymes to Dicarbonyl Stress
by: Leigh Donnellan, et al.
Published: (2022-03-01)

Hypothesis: The opposing pulling forces exerted by spindle microtubules can cause sliding of chromatin layers and facilitate sister chromatid resolution
by: Joan-Ramon Daban
Published: (2023-11-01)

<i>In Vitro</i> genotoxic and antigenotoxic studies of Thai Noni fruit juice by chromosomal aberration and sister chromatid exchange assays in human lymphocytes
by: Treetip Ratanavalachai, et al.
Published: (2008-09-01)

A study of sister chromatid exchange in patients with dental amalgam restorations
by: E Lakshmi Priya, et al.
Published: (2014-01-01)

The Sister Chromatid Division of the Heteromorphic Sex Chromosomes in <i>Silene</i> Species and Their Transmissibility towards the Mitosis
by: Václav Bačovský, et al.
Published: (2022-02-01)

Functional Coupling between DNA Replication and Sister Chromatid Cohesion Establishment
by: Ana Boavida, et al.
Published: (2021-03-01)

Variations in dysfunction of sister chromatid cohesion in esco2 mutant zebrafish reflect the phenotypic diversity of Roberts syndrome
by: Stefanie M. Percival, et al.
Published: (2015-08-01)

ATM Promotes RAD51-Mediated Meiotic DSB Repair by Inter-Sister-Chromatid Recombination in Arabidopsis
by: Yuan Yao, et al.
Published: (2020-06-01)

MCM2–7-dependent cohesin loading during S phase promotes sister-chromatid cohesion
by: Ge Zheng, et al.
Published: (2018-04-01)

Discovering non-random segregation of sister chromatids: The naïve treatment of a premature discovery
by: Karl G. Lark
Published: (2013-02-01)

Towards a Structural Mechanism for Sister Chromatid Cohesion Establishment at the Eukaryotic Replication Fork
by: Sarah S. Henrikus, et al.
Published: (2021-05-01)

Integrating Sister Chromatid Cohesion Establishment to DNA Replication
by: Caitlin M. Zuilkoski, et al.
Published: (2022-03-01)

Chromatin assembly factor-1 preserves genome stability in ctf4∆ cells by promoting sister chromatid cohesion
by: Nagham Ghaddar, et al.
Published: (2023-08-01)

Comparison of genome stability in two pig breeds by using the sister chromatid exchange (SCE) test
by: V. Barbieri, et al.
Published: (2010-01-01)

Effect of Upregulated DNA Replication and Sister Chromatid Cohesion 1 Expression on Proliferation and Prognosis in Hepatocellular Carcinoma
by: Xing-Wang Xie, et al.
Published: (2018-01-01)

Evaluation of Sister Chromatid Exchanges and Hypoxanthine guanine phosphoribosyl transferase Gene Mutation Assay in Peripheral Lymphocytes of Workers Exposed to Radiation at Al-Tuwaitha Site
by: Abdulsahib K. Ali
Published: (2015-12-01)

E3 ubiquitin ligase Bre1 couples sister chromatid cohesion establishment to DNA replication in Saccharomyces cerevisiae
by: Wei Zhang, et al.
Published: (2017-10-01)

EdU-Based Step-by-Step Method for the Detection of Sister Chromatid Exchanges for Application in Plant Genotoxicity Assessment
by: Jolanta Kwasniewska, et al.
Published: (2020-07-01)

Cohesin-interacting protein WAPL-1 regulates meiotic chromosome structure and cohesion by antagonizing specific cohesin complexes
by: Oliver Crawley, et al.
Published: (2016-02-01)

Genotoxic effects of copper sulfate in rabbits
by: Georgieva S., et al.
Published: (2013-01-01)

The genoprotective activity of resveratrol on permethrin-induced genotoxic damage in cultured human lymphocytes
by: Hasan Turkez, et al.
Published: (2013-06-01)

Gorlin Syndrome in Eleven Patients
by: Gülen Eda Utine, et al.
Published: (2017-06-01)

Mechanisms of telomere loss and their consequences for chromosome instability
by: Keiko eMuraki, et al.
Published: (2012-10-01)

Genome-wide mapping of sister chromatid exchange events in single yeast cells using Strand-seq
by: Clémence Claussin, et al.
Published: (2017-12-01)

Genotoxicity of Mercury and Its Derivatives Demonstrated In Vitro and In Vivo in Human Populations Studies. Systematic Review
by: Juana Sánchez-Alarcón, et al.
Published: (2021-12-01)

Chromosome fragility in Freemartin cattle
by: V. Barbieri, et al.
Published: (2010-04-01)

Chiasmata and the kinetochore component Dam1 are crucial for elimination of erroneous chromosome attachments and centromere oscillation at meiosis I
by: Misuzu Wakiya, et al.
Published: (2021-02-01)

Terminalia catappa, an anticlastogenic agent against MMS induced genotoxicity in the human lymphocyte culture and in bone marrow cells of Albino mice
by: Mohammad Sultan Ahmad, et al.
Published: (2014-07-01)

Loss, Gain, and Retention: Mechanisms Driving Late Prophase I Chromosome Remodeling for Accurate Meiotic Chromosome Segregation
by: Laura I. Láscarez-Lagunas, et al.
Published: (2022-03-01)

Andrographia paniculata a Miracle Herbs for cancer treatment: In vivo and in vitro studies against Aflatoxin B1 Toxicity
by: Md. Sultan Ahmad, et al.
Published: (2014-04-01)

Cancer ameliorating potential of Phyllanthus amarus: In vivo and in vitro studies against Aflatoxin B1 toxicity
by: Md. Sultan Ahmad, et al.
Published: (2015-10-01)

Is age‐related increase of chromosome segregation errors in mammalian oocytes caused by cohesin deterioration?
by: Jibak Lee
Published: (2020-01-01)

Structural evidence for Scc4-dependent localization of cohesin loading
by: Stephen M Hinshaw, et al.
Published: (2015-06-01)

Folding of cohesin’s coiled coil is important for Scc2/4-induced association with chromosomes
by: Naomi J Petela, et al.
Published: (2021-07-01)

MicroRNA-449a Inhibits Triple Negative Breast Cancer by Disturbing DNA Repair and Chromatid Separation
by: Beate Vajen, et al.
Published: (2022-05-01)