FoxO1 inhibition alleviates type 2 diabetes-related diastolic dysfunction by increasing myocardial pyruvate dehydrogenase activity

FoxO1 inhibition alleviates type 2 diabetes-related diastolic dysfunction by increasing myocardial pyruvate dehydrogenase activity

Summary: Type 2 diabetes (T2D) increases the risk for diabetic cardiomyopathy and is characterized by diastolic dysfunction. Myocardial forkhead box O1 (FoxO1) activity is enhanced in T2D and upregulates pyruvate dehydrogenase (PDH) kinase 4 expression, which inhibits PDH activity, the rate-limiting...

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Bibliographic Details
Main Authors: Keshav Gopal, Rami Al Batran, Tariq R. Altamimi, Amanda A. Greenwell, Christina T. Saed, Seyed Amirhossein Tabatabaei Dakhili, M. Toni E. Dimaano, Yongneng Zhang, Farah Eaton, Gopinath Sutendra, John R. Ussher
Format: Article
Language:English
Published: Elsevier 2021-04-01
Series:Cell Reports
Subjects:
FoxO1
pyruvate dehydrogenase
glucose oxidation
diabetic cardiomyopathy
diastolic dysfunction
type 2 diabetes
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721002497

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http://www.sciencedirect.com/science/article/pii/S2211124721002497

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