Morpholino-Mediated Isoform Modulation of Vascular Endothelial Growth Factor Receptor-2 (VEGFR2) Reduces Colon Cancer Xenograft Growth

Morpholino-Mediated Isoform Modulation of Vascular Endothelial Growth Factor Receptor-2 (VEGFR2) Reduces Colon Cancer Xenograft Growth

Angiogenesis plays a key role in tumor growth. Vascular endothelial growth factor (VEGF) is a pro-angiogenic that is involved in tumor angiogenesis. When VEGF binds to membrane-bound vascular endothelial growth factor receptor 2 (mVEGFR2), it promotes angiogenesis. Through alternative polyadenylatio...

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Bibliographic Details
Main Authors: Brian C. Stagg, Hironori Uehara, Nathan Lambert, Ruju Rai, Isha Gupta, Bryce Radmall, Taylor Bates, Balamurali K. Ambati
Format: Article
Language:English
Published: MDPI AG 2014-11-01
Series:Cancers
Subjects:
VEGFR2, angiogenesis inhibitors, morpholinos, alternative polyadenylation
Online Access:http://www.mdpi.com/2072-6694/6/4/2330

Internet

http://www.mdpi.com/2072-6694/6/4/2330

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