Bioanalytical method development and validation for the simultaneous estimation of Olanzapine and Samidorphan in rabbit plasma by using HPLC–MS/MS and application to pharmacokinetic study

Bioanalytical method development and validation for the simultaneous estimation of Olanzapine and Samidorphan in rabbit plasma by using HPLC–MS/MS and application to pharmacokinetic study

Abstract Background Samidorphan is an opioid antagonist while Olanzapine is an effective medication for schizophrenia and bipolar disorder. A unique and accurate MS/HPLC approach due to simultaneous measurement of Olanzapine and Samidorphan is, therefore, more urgently required. Simultaneous quantif...

Full description

Bibliographic Details
Main Authors: Rambabu Kantipudi, Sugandha Kumar Pavuluri
Format: Article
Language:English
Published: SpringerOpen 2024-01-01
Series:Future Journal of Pharmaceutical Sciences
Subjects:
Development
HPLC–MS/MS
Olanzapine
Samidorphan
Validation
Rabbit plasma
Online Access:https://doi.org/10.1186/s43094-023-00570-5

Internet

https://doi.org/10.1186/s43094-023-00570-5

Similar Items