The ubiquitin-conjugating enzyme UBE2O modulates c-Maf stability and induces myeloma cell apoptosis

The ubiquitin-conjugating enzyme UBE2O modulates c-Maf stability and induces myeloma cell apoptosis

Abstract Background UBE2O is proposed as a ubiquitin-conjugating enzyme, but its function was largely unknown. Methods Mass spectrometry was applied to identify c-Maf ubiquitination-associated proteins. Immunoprecipitation was applied for c-Maf and UBE2O interaction. Immunoblotting was used for Maf...

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Dettagli Bibliografici
Autori principali: Yujia Xu, Zubin Zhang, Jie Li, Jiefei Tong, Biyin Cao, Paul Taylor, Xiaowen Tang, Depei Wu, Michael F. Moran, Yuanying Zeng, Xinliang Mao
Natura: Articolo
Lingua:English
Pubblicazione: BMC 2017-07-01
Serie:Journal of Hematology & Oncology
Soggetti:
c-Maf
UBE2O
Ubiquitin proteasome pathway
Multiple myeloma
Accesso online:http://link.springer.com/article/10.1186/s13045-017-0499-7

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http://link.springer.com/article/10.1186/s13045-017-0499-7

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