Thrombin-induced delayed injury involves multiple and distinct signaling pathways in the cerebral cortex and the striatum in organotypic slice cultures

Thrombin-induced delayed injury involves multiple and distinct signaling pathways in the cerebral cortex and the striatum in organotypic slice cultures

Thrombin, a serine protease essential for blood coagulation, also plays an important role in cellular injury associated with intracerebral hemorrhage. Here, we show that, in organotypic cortico-striatal slice cultures, thrombin evoked delayed neuronal injury in the cerebral cortex and shrinkage of t...

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Bibliographic Details
Main Authors: Shinji Fujimoto, Hiroshi Katsuki, Toshiaki Kume, Akinori Akaike
Format: Article
Language:English
Published: Elsevier 2006-04-01
Series:Neurobiology of Disease
Subjects:
Apoptosis
Intracerebral hemorrhage
Mitogen-activated protein kinase
Neurodegeneration
Oxidative stress
Thrombin
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996105002792

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http://www.sciencedirect.com/science/article/pii/S0969996105002792

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