Lgr5-positive endothelial progenitor cells occupy a tumor and injury prone niche in the kidney vasa recta

Lgr5-positive endothelial progenitor cells occupy a tumor and injury prone niche in the kidney vasa recta

The Wnt pathway co-receptor, Leucine Rich Repeat Containing G Protein-Coupled Receptor 5 (LGR5), labels tumor-prone stem cell populations in certain types of tissue. In this study, we show that ARID1A and PIK3CA mutations in LGR5+ cells result in renal angiosarcomas in adult mice. The tumors origina...

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Bibliographic Details
Main Authors: Mike R. Wilson, Jeanne Holladay, Rachael Sheridan, Galen Hostetter, Bree Berghuis, Carrie Graveel, Curt Essenburg, Anderson Peck, Thai H. Ho, Melissa Stanton, Ronald L. Chandler
Format: Article
Language:English
Published: Elsevier 2020-07-01
Series:Stem Cell Research
Subjects:
Vasa recta
Stem cells
Acute kidney injury
Ischemia
Online Access:http://www.sciencedirect.com/science/article/pii/S1873506120301501

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http://www.sciencedirect.com/science/article/pii/S1873506120301501

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