Integration of Fungus-Specific CandA-C1 into a Trimeric CandA Complex Allowed Splitting of the Gene for the Conserved Receptor Exchange Factor of CullinA E3 Ubiquitin Ligases in Aspergilli

Integration of Fungus-Specific CandA-C1 into a Trimeric CandA Complex Allowed Splitting of the Gene for the Conserved Receptor Exchange Factor of CullinA E3 Ubiquitin Ligases in Aspergilli

ABSTRACT E3 cullin-RING ubiquitin ligase (CRL) complexes recognize specific substrates and are activated by covalent modification with ubiquitin-like Nedd8. Deneddylation inactivates CRLs and allows Cand1/A to bind and exchange substrate recognition subunits. Human as well as most fungi possess a si...

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Bibliographic Details
Main Authors: Anna M. Köhler, Rebekka Harting, Annika E. Langeneckert, Oliver Valerius, Jennifer Gerke, Cindy Meister, Anja Strohdiek, Gerhard H. Braus
Format: Article
Language:English
Published: American Society for Microbiology 2019-06-01
Series:mBio
Subjects:
Aspergillus fumigatus
Aspergillus nidulans
COP9 signalosome
Cand1
Cullin-RING ubiquitin ligase
Nedd8
Online Access:https://journals.asm.org/doi/10.1128/mBio.01094-19

Internet

https://journals.asm.org/doi/10.1128/mBio.01094-19

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