A population pharmacokinetic model is beneficial in quantifying hair concentrations of ritonavir-boosted atazanavir: a study of HIV-infected Zimbabwean adolescents

A population pharmacokinetic model is beneficial in quantifying hair concentrations of ritonavir-boosted atazanavir: a study of HIV-infected Zimbabwean adolescents

Abstract Background Adolescents experience higher levels of non-adherence to HIV treatment. Drug concentration in hair promises to be reliable for assessing exposure to antiretroviral (ARV) drugs. Pharmacokinetic modelling can explore utility of drug in hair. We aimed at developing and validating a...

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Bibliographic Details
Main Authors: Bernard Ngara, Simbarashe Zvada, Tariro Dianah Chawana, Babill Stray-Pedersen, Charles Fungai Brian Nhachi, Simbarashe Rusakaniko
Format: Article
Language:English
Published: BMC 2020-08-01
Series:BMC Pharmacology and Toxicology
Subjects:
Pharmacokinetic modelling
HIV/AIDS
Adolescents
Adherence
Hair
NONMEM
Online Access:http://link.springer.com/article/10.1186/s40360-020-00437-y

Internet

http://link.springer.com/article/10.1186/s40360-020-00437-y

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