GDNF-based therapies, GDNF-producing interneurons, and trophic support of the dopaminergic nigrostriatal pathway. Implications for Parkinson’s disease

GDNF-based therapies, GDNF-producing interneurons, and trophic support of the dopaminergic nigrostriatal pathway. Implications for Parkinson’s disease

The glial cell line-derived neurotrophic factor (GDNF) is a well-established trophic agent for dopaminergic (DA) neurons in vitro and in vivo. GDNF is necessary for maintenance of neuronal morphological and neurochemical phenotype and protects DA neurons from toxic damage. Numerous studies on animal...

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Bibliographic Details
Main Authors: Xavier ed'Anglemont De Tassigny, Alberto ePascual, Jose eLopez-Barneo
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-02-01
Series:Frontiers in Neuroanatomy
Subjects:
Parkinson Disease
Striatum
mouse models
dopaminergic system
neurotrophic factors
Nigrostriatal pathway
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnana.2015.00010/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnana.2015.00010/full

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