Histamine H4 Receptor Antagonist Ameliorates the Progression of Experimental Autoimmune Encephalomyelitis via Regulation of T-Cell Imbalance

Histamine H4 Receptor Antagonist Ameliorates the Progression of Experimental Autoimmune Encephalomyelitis via Regulation of T-Cell Imbalance

Multiple sclerosis (MS) is a degenerative condition characterized by immune-mediated attacks on the central nervous system (CNS), resulting in demyelination and recurring T-cell responses. The histamine H4 receptor (H4R) is mainly expressed in cellular populations and plays a vital role in inflammat...

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Bibliographic Details
Main Authors: Abdullah A. Aldossari, Mohammed A. Assiri, Mushtaq A. Ansari, Ahmed Nadeem, Sabry M. Attia, Saleh A. Bakheet, Thamer H. Albekairi, Hatun A. Alomar, Haneen A. Al-Mazroua, Taghreed N. Almanaa, Mohammed A. Al-Hamamah, Mohammad Y. Alwetaid, Sheikh F. Ahmad
Format: Article
Language:English
Published: MDPI AG 2023-10-01
Series:International Journal of Molecular Sciences
Subjects:
H4R antagonist
JNJ 10191584
EAE
multiple sclerosis
inflammatory mediators transcription factors
Online Access:https://www.mdpi.com/1422-0067/24/20/15273

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https://www.mdpi.com/1422-0067/24/20/15273

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