c-Abl Inhibition Activates TFEB and Promotes Cellular Clearance in a Lysosomal Disorder

c-Abl Inhibition Activates TFEB and Promotes Cellular Clearance in a Lysosomal Disorder

Summary: The transcription factor EB (TFEB) has emerged as a master regulator of lysosomal biogenesis, exocytosis, and autophagy, promoting the clearance of substrates stored in cells. c-Abl is a tyrosine kinase that participates in cellular signaling in physiological and pathophysiological conditio...

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Bibliographic Details
Main Authors: Pablo S. Contreras, Pablo J. Tapia, Lila González-Hódar, Ivana Peluso, Chiara Soldati, Gennaro Napolitano, Maria Matarese, Macarena Las Heras, Cristian Valls, Alexis Martinez, Elisa Balboa, Juan Castro, Nancy Leal, Frances M. Platt, Andrzej Sobota, Dominic Winter, Andrés D. Klein, Diego L. Medina, Andrea Ballabio, Alejandra R. Alvarez, Silvana Zanlungo
Format: Article
Language:English
Published: Elsevier 2020-11-01
Series:iScience
Subjects:
Biological Sciences
Molecular Biology
Cell Biology
Online Access:http://www.sciencedirect.com/science/article/pii/S258900422030883X

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http://www.sciencedirect.com/science/article/pii/S258900422030883X

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