Modulation of cytomegalovirus immune evasion identifies direct antigen presentation as the predominant mode of CD8 T-cell priming during immune reconstitution after hematopoietic cell transplantation

Modulation of cytomegalovirus immune evasion identifies direct antigen presentation as the predominant mode of CD8 T-cell priming during immune reconstitution after hematopoietic cell transplantation

Cytomegalovirus (CMV) infection is the most critical infectious complication in recipients of hematopoietic cell transplantation (HCT) in the period between a therapeutic hematoablative treatment and the hematopoietic reconstitution of the immune system. Clinical investigation as well as the mouse m...

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Bibliographic Details
Main Authors: Rafaela Holtappels, Julia K. Büttner, Kirsten Freitag, Matthias J. Reddehase, Niels A. Lemmermann
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-02-01
Series:Frontiers in Immunology
Subjects:
antigen cross-presentation
CD8 T-cell priming
direct antigen presentation
effector-memory T cells (TEM)
immune evasion
latent infection
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1355153/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2024.1355153/full

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