Intraoral Drug Delivery: Highly Thiolated κ-Carrageenan as Mucoadhesive Excipient

Intraoral Drug Delivery: Highly Thiolated κ-Carrageenan as Mucoadhesive Excipient

Aim: This study aims to design a novel thiolated κ-carrageenan (κ-CA-SH) and evaluate its potential as an excipient for the design of mucoadhesive drug delivery systems. Methods: Native κ-carrageenan (κ-CA) was thiolated with phosphorous pentasulfide in sulfolane and characterized via <sup>1&l...

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Bibliographic Details
Main Authors: Gergely Kali, Andrea Fürst, Nuri Ari Efiana, Aida Dizdarević, Andreas Bernkop-Schnürch
Format: Article
Language:English
Published: MDPI AG 2023-07-01
Series:Pharmaceutics
Subjects:
Carrageenan
thiomers
thiolated kappa-carrageenan
mucoadhesion
mucosal residence time
Online Access:https://www.mdpi.com/1999-4923/15/7/1993

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https://www.mdpi.com/1999-4923/15/7/1993

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