Holothurian triterpene glycoside cucumarioside A2-2 induces macrophages activation and polarization in cancer immunotherapy

Holothurian triterpene glycoside cucumarioside A2-2 induces macrophages activation and polarization in cancer immunotherapy

Abstract Background Despite intensive developments of adoptive T cell and NK cell therapies, the efficacy against solid tumors remains elusive. Our study demonstrates that macrophage-based cell therapy could be a potent therapeutic option against solid tumors. Methods To this end, we determine the e...

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Bibliographic Details
Main Authors: Wen-Han Chuang, Evgeny Pislyagin, Liang-Yu Lin, Ekaterina Menchinskaya, Oleg Chernikov, Valery Kozhemyako, Tatiana Gorpenchenko, Igor Manzhulo, Elena Chaikina, Irina Agafonova, Alexandra Silchenko, Sergey Avilov, Valentin Stonik, Shey-Cherng Tzou, Dmitry Aminin, Yun-Ming Wang
Format: Article
Language:English
Published: BMC 2023-11-01
Series:Cancer Cell International
Subjects:
Holothurian triterpene glycoside
Cucumarioside A2-2
Anticancer
M1 macrophage
Immunotherapy
Online Access:https://doi.org/10.1186/s12935-023-03141-z

Internet

https://doi.org/10.1186/s12935-023-03141-z

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