Sepsis promotes splenic production of a protective platelet pool with high CD40 ligand expression

Sepsis promotes splenic production of a protective platelet pool with high CD40 ligand expression

Platelets have a wide range of functions including critical roles in hemostasis, thrombosis, and immunity. We hypothesized that during acute inflammation, such as in life-threatening sepsis, there are fundamental changes in the sites of platelet production and phenotypes of resultant platelets. Here...

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Bibliographic Details
Main Authors: Colin Valet, Mélia Magnen, Longhui Qiu, Simon J. Cleary, Kristin M. Wang, Serena Ranucci, Elodie Grockowiak, Rafik Boudra, Catharina Conrad, Yurim Seo, Daniel R. Calabrese, John R. Greenland, Andrew D. Leavitt, Emmanuelle Passegué, Simón Méndez-Ferrer, Filip K. Swirski, Mark R. Looney
Format: Article
Language:English
Published: American Society for Clinical Investigation 2022-04-01
Series:The Journal of Clinical Investigation
Subjects:
Hematology
Stem cells
Online Access:https://doi.org/10.1172/JCI153920

Internet

https://doi.org/10.1172/JCI153920

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