MiR-21-5p regulates the dynamic of mitochondria network and rejuvenates the senile phenotype of bone marrow stromal cells (BMSCs) isolated from osteoporotic SAM/P6 mice

MiR-21-5p regulates the dynamic of mitochondria network and rejuvenates the senile phenotype of bone marrow stromal cells (BMSCs) isolated from osteoporotic SAM/P6 mice

Abstract Background Progression of senile osteoporosis is associated with deteriorated regenerative potential of bone marrow-derived mesenchymal stem/stromal cells (BMSCs). According to the recent results, the senescent phenotype of osteoporotic cells strongly correlates with impaired regulation of...

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Bibliographic Details
Main Authors: Mateusz Sikora, Agnieszka Śmieszek, Ariadna Pielok, Krzysztof Marycz
Format: Article
Language:English
Published: BMC 2023-03-01
Series:Stem Cell Research & Therapy
Subjects:
miR-21
Senile osteoporosis
Bone regeneration
Mitochondria dynamic
BMSCs
SAM/P6 mice
Online Access:https://doi.org/10.1186/s13287-023-03271-1

Internet

https://doi.org/10.1186/s13287-023-03271-1

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