Vasoactive intestinal peptide blockade suppresses tumor growth by regulating macrophage polarization and function in CT26 tumor-bearing mice

Vasoactive intestinal peptide blockade suppresses tumor growth by regulating macrophage polarization and function in CT26 tumor-bearing mice

Abstract Macrophages are a major population of immune cells in solid cancers, especially colorectal cancers. Tumor-associated macrophages (TAMs) are commonly divided into M1-like (tumor suppression) and M2-like (tumor promotion) phenotypes. Vasoactive intestinal peptide (VIP) is an immunoregulatory...

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Bibliographic Details
Main Authors: Wararat Kittikulsuth, Daisuke Nakano, Kento Kitada, Toru Uyama, Natsuo Ueda, Eisuke Asano, Keiichi Okano, Yoko Matsuda, Akira Nishiyama
Format: Article
Language:English
Published: Nature Portfolio 2023-01-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-28073-6

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https://doi.org/10.1038/s41598-023-28073-6

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