Molecular Pharmacology of P2X Receptors: Exploring Druggable Domains Revealed by Structural Biology

Molecular Pharmacology of P2X Receptors: Exploring Druggable Domains Revealed by Structural Biology

Extracellular ATP is a critical signaling molecule that is found in a wide range of concentrations across cellular environments. The family of nonselective cation channels that sense extracellular ATP, termed P2X receptors (P2XRs), is composed of seven subtypes (P2X1-P2X7) that assemble as functiona...

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Bibliographic Details
Main Authors: Adam C. Oken, Ipsita Krishnamurthy, Jonathan C. Savage, Nicolas E. Lisi, Michael H. Godsey, Steven E. Mansoor
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Pharmacology
Subjects:
purinergic receptors
P2X
ion channels
cryo-EM
X-ray crystallography
antagonist
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.925880/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.925880/full

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