Conformational Plasticity of Hepatitis B Core Protein Spikes Promotes Peptide Binding Independent of the Secretion Phenotype

Conformational Plasticity of Hepatitis B Core Protein Spikes Promotes Peptide Binding Independent of the Secretion Phenotype

Hepatitis B virus is a major human pathogen, which forms enveloped virus particles. During viral maturation, membrane-bound hepatitis B surface proteins package hepatitis B core protein capsids. This process is intercepted by certain peptides with an “LLGRMKG” motif that binds to the capsids at the...

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Bibliographic Details
Main Authors: Cihan Makbul, Vladimir Khayenko, Hans Michael Maric, Bettina Böttcher
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Microorganisms
Subjects:
hepatitis B core protein
hepatitis B virus
peptide inhibitor of envelopment
isothermal titration calorimetry
electron cryo microscopy
low-secretion phenotype mutants
Online Access:https://www.mdpi.com/2076-2607/9/5/956

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https://www.mdpi.com/2076-2607/9/5/956

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