Subgenomic particles in rAAV vectors result from DNA lesion/break and non-homologous end joining of vector genomes

Subgenomic particles in rAAV vectors result from DNA lesion/break and non-homologous end joining of vector genomes

Recombinant adeno-associated virus (rAAV) vectors have been developed for therapeutic treatment of genetic diseases. Current rAAV vectors administered to affected individuals often contain vector DNA-related contaminants. Here we present a thorough molecular analysis of the configuration of non-stan...

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Bibliographic Details
Main Authors: Junping Zhang, Ping Guo, Xiangping Yu, Dylan A. Frabutt, Anh K. Lam, Patrick L. Mulcrone, Matthew Chrzanowski, Jenni Firrman, Derek Pouchnik, Nianli Sang, Yong Diao, Roland W. Herzog, Weidong Xiao
Format: Article
Language:English
Published: Elsevier 2022-09-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
MT: Oligonucleotides
Therapies and Applications
recombinant adeno-associated virus (rAAV) vectors
subgenomic particles
DNA lesion/break
non-homologous end joining
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253122002268

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http://www.sciencedirect.com/science/article/pii/S2162253122002268

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