Characterization of CEBPA mutations and promoter hypermethylation in pediatric acute myeloid leukemia

Characterization of CEBPA mutations and promoter hypermethylation in pediatric acute myeloid leukemia

Background Dysfunctioning of CCAAT/enhancer binding protein α (C/EBPα) in acute myeloid leukemia can be caused, amongst others, by mutations in the encoding gene (CEBPA) and by promoter hypermethylation. CEBPA-mutated acute myeloid leukemia is associated with a favorable outcome, but this may be res...

Full description

Bibliographic Details
Main Authors: Iris H.I.M. Hollink, Marry M. van den Heuvel-Eibrink, Susan T.C.J.M. Arentsen-Peters, Martin Zimmermann, Justine K. Peeters, Peter J.M. Valk, Brian V. Balgobind, Edwin Sonneveld, Gertjan J.L. Kaspers, Eveline S.J.M. de Bont, Jan Trka, Andre Baruchel, Ursula Creutzig, Rob Pieters, Dirk Reinhardt, C. Michel Zwaan
Format: Article
Language:English
Published: Ferrata Storti Foundation 2011-03-01
Series:Haematologica
Online Access:https://haematologica.org/article/view/5900

Internet

https://haematologica.org/article/view/5900

Similar Items