Discovery of 7-Azanorbornane-Based Dual Agonists for the Delta and Kappa Opioid Receptors through an In Situ Screening Protocol

Discovery of 7-Azanorbornane-Based Dual Agonists for the Delta and Kappa Opioid Receptors through an In Situ Screening Protocol

In medicinal chemistry, the copper-catalyzed click reaction is used to prepare ligand candidates. This reaction is so clean that the bioactivities of the products can be determined without purification. Despite the advantages of this in situ screening protocol, the applicability of this method for t...

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Bibliographic Details
Main Authors: Fumika Karaki, Taro Takamori, Koumei Kawakami, Sae Sakurai, Kyoko Hidaka, Kei Ishii, Tomoya Oki, Noriko Sato, Nao Atsumi, Karin Ashizawa, Ai Taguchi, Asuka Ura, Toko Naruse, Shigeto Hirayama, Miki Nonaka, Kanako Miyano, Yasuhito Uezono, Hideaki Fujii
Format: Article
Language:English
Published: MDPI AG 2023-10-01
Series:Molecules
Subjects:
opioid receptor
in situ screening
click reaction
dual agonist
polypharmacology
analgesics
Online Access:https://www.mdpi.com/1420-3049/28/19/6925

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https://www.mdpi.com/1420-3049/28/19/6925

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