Sox2 induces glioblastoma cell stemness and tumor propagation by repressing TET2 and deregulating 5hmC and 5mC DNA modifications

Sox2 induces glioblastoma cell stemness and tumor propagation by repressing TET2 and deregulating 5hmC and 5mC DNA modifications

Abstract DNA methylation is a reversible process catalyzed by the ten–eleven translocation (TET) family of enzymes (TET1, TET2, TET3) that convert 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC). Altered patterns of 5hmC and 5mC are widely reported in human cancers and loss of 5hmC correlat...

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Bibliographic Details
Main Authors: Hernando Lopez-Bertoni, Amanda Johnson, Yuan Rui, Bachchu Lal, Sophie Sall, Maureen Malloy, Jonathan B. Coulter, Maria Lugo-Fagundo, Sweta Shudir, Harmon Khela, Christopher Caputo, Jordan J. Green, John Laterra
Format: Article
Language:English
Published: Nature Publishing Group 2022-02-01
Series:Signal Transduction and Targeted Therapy
Online Access:https://doi.org/10.1038/s41392-021-00857-0

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https://doi.org/10.1038/s41392-021-00857-0

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