Evidence for evolutionary divergence of activity-dependent gene expression in developing neurons

Evidence for evolutionary divergence of activity-dependent gene expression in developing neurons

Evolutionary differences in gene regulation between humans and lower mammalian experimental systems are incompletely understood, a potential translational obstacle that is challenging to surmount in neurons, where primary tissue availability is poor. Rodent-based studies show that activity-dependent...

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Bibliographic Details
Main Authors: Jing Qiu, Jamie McQueen, Bilada Bilican, Owen Dando, Dario Magnani, Karolina Punovuori, Bhuvaneish T Selvaraj, Matthew Livesey, Ghazal Haghi, Samuel Heron, Karen Burr, Rickie Patani, Rinku Rajan, Olivia Sheppard, Peter C Kind, T Ian Simpson, Victor LJ Tybulewicz, David JA Wyllie, Elizabeth MC Fisher, Sally Lowell, Siddharthan Chandran, Giles E Hardingham
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-10-01
Series:eLife
Subjects:
transcription
gene expression
calcium signaling
neuronal activity
Online Access:https://elifesciences.org/articles/20337

Internet

https://elifesciences.org/articles/20337

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