TRAF4‐Mediated LAMTOR1 Ubiquitination Promotes mTORC1 Activation and Inhibits the Inflammation‐Induced Colorectal Cancer Progression

TRAF4‐Mediated LAMTOR1 Ubiquitination Promotes mTORC1 Activation and Inhibits the Inflammation‐Induced Colorectal Cancer Progression

Abstract Mechanistic target of rapamycin complex 1 (mTORC1) is a conserved serine/threonine kinase that integrates various environmental signals to regulate cell growth and metabolism. mTORC1 activation requires tethering to lysosomes by the Ragulator‐Rag complex. However, the dynamic regulation of...

ver descrição completa

Detalhes bibliográficos
Main Authors: Linlin Zhao, Ni Gao, Xiaoping Peng, Lei Chen, Tong Meng, Cong Jiang, Jiali Jin, Jiawen Zhang, Qiuhui Duan, Hongling Tian, Linjun Weng, Xinbo Wang, Xiao Tan, Yaxu Li, Huanlong Qin, Jian Yuan, Xin Ge, Lu Deng, Ping Wang
Formato: Artigo
Idioma:English
Publicado em: Wiley 2024-03-01
Colecção:Advanced Science
Assuntos:
LAMTOR1
mTORC1
Rag GTPase
TRAF4
ubiquitination
Acesso em linha:https://doi.org/10.1002/advs.202301164

Internet

https://doi.org/10.1002/advs.202301164

Registos relacionados