α-Lipoic Acid Protects against Cyclosporine A-Induced Hepatic Toxicity in Rats: Effect on Oxidative Stress, Inflammation, and Apoptosis

α-Lipoic Acid Protects against Cyclosporine A-Induced Hepatic Toxicity in Rats: Effect on Oxidative Stress, Inflammation, and Apoptosis

The clinical application of cyclosporine A (CsA) as an immunosuppressive agent is limited by its organ toxicity. We aimed to evaluate the effectiveness of α-lipoic acid against CsA-induced hepatotoxicity and to delineate the underlying molecular mechanisms. Male Wistar rats (<i>n</i> = 2...

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Bibliographic Details
Main Authors: Eman M. El-Mancy, Dalia Mahmoud Abdelmonem Elsherbini, Rasha Hamed Al-Serwi, Mohamed El-Sherbiny, Gehan Ahmed Shaker, Abdel-Moneim Hafez Abdel-Moneim, Eman T. Enan, Nehal M. Elsherbiny
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Toxics
Subjects:
cyclosporine A
liver
oxidative stress
inflammation
apoptosis
Online Access:https://www.mdpi.com/2305-6304/10/8/442

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https://www.mdpi.com/2305-6304/10/8/442

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