Omega-3 fatty acid-based self-microemulsifying drug delivery system (SMEDDS) of pioglitazone: Optimization, in vitro and in vivo studies

Omega-3 fatty acid-based self-microemulsifying drug delivery system (SMEDDS) of pioglitazone: Optimization, in vitro and in vivo studies

Pioglitazone (PGL) is an effective insulin sensitizer, however, side effects such as accumulation of subcutaneous fat, edema, and weight gain as well as poor oral bioavailability limit its therapeutic potential for oral delivery. Recent studies have shown that combination of both, PGL and fish oil s...

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Bibliographic Details
Main Authors: Nasr A. Emad, Yasmin Sultana, Mohd Aqil, Asmaa Saleh, Omkulthom Al kamaly, Fahd A Nasr
Format: Article
Language:English
Published: Elsevier 2023-09-01
Series:Saudi Journal of Biological Sciences
Subjects:
Nanoparticles
Pioglitazone
Omega-3 fatty acid
SMEDDS
Insulin resistance
Pharmacokinetics
Online Access:http://www.sciencedirect.com/science/article/pii/S1319562X23002231

Internet

http://www.sciencedirect.com/science/article/pii/S1319562X23002231

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