Cholesterol efflux regulator ABCA1 exerts protective role against high shear stress-induced injury of HBMECs via regulating PI3K/Akt/eNOS signaling

Cholesterol efflux regulator ABCA1 exerts protective role against high shear stress-induced injury of HBMECs via regulating PI3K/Akt/eNOS signaling

Abstract Background In brain, microvascular endothelial cells are exposed to various forces, including shear stress (SS). However, little is known about the effects of high shear stress (HSS) on human brain microvascular endothelial cells (HBMECs) and the underlying mechanism. The cholesterol efflux...

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Bibliographic Details
Main Authors: Zhe Li, Jia-Nan Li, Qiang Li, Chun Liu, Lin-Hua Zhou, Qi Zhang, Yi Xu
Format: Article
Language:English
Published: BMC 2022-11-01
Series:BMC Neuroscience
Subjects:
ABCA1
Atherosclerosis
Cholesterol efflux
High shear stress
Human brain microvascular endothelial cells
PI3K/Akt/eNOS pathway
Online Access:https://doi.org/10.1186/s12868-022-00748-2

Internet

https://doi.org/10.1186/s12868-022-00748-2

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