Isoquinoline Antimicrobial Agent: Activity against Intracellular Bacteria and Effect on Global Bacterial Proteome

Isoquinoline Antimicrobial Agent: Activity against Intracellular Bacteria and Effect on Global Bacterial Proteome

A new class of alkynyl isoquinoline antibacterial compounds, synthesized via Sonogashira coupling, with strong bactericidal activity against a plethora of Gram-positive bacteria including methicillin- and vancomycin-resistant <i>Staphylococcus aureus (S. aureus)</i> strains is presented....

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Bibliographic Details
Main Authors: Caroline W. Karanja, Nimishetti Naganna, Nader S. Abutaleb, Neetu Dayal, Kenneth I. Onyedibe, Uma Aryal, Mohamed N. Seleem, Herman O. Sintim
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Molecules
Subjects:
antimicrobial resistance
allkynyl isoquinolies
Sonogashira coupling
intracellular clearance
Online Access:https://www.mdpi.com/1420-3049/27/16/5085

Internet

https://www.mdpi.com/1420-3049/27/16/5085

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