Metformin causes a futile intestinal–hepatic cycle which increases energy expenditure and slows down development of a type 2 diabetes-like state

Metformin causes a futile intestinal–hepatic cycle which increases energy expenditure and slows down development of a type 2 diabetes-like state

Objective: Metformin, the first line drug for treatment of type 2 diabetes, suppresses hepatic gluconeogenesis and reduces body weight in patients, the latter by an unknown mechanism. Methods: Mice on a high fat diet were continuously fed metformin in a therapeutically relevant dose, mimicking a ret...

Full description

Bibliographic Details
Main Authors: Philipp Schommers, Anna Thurau, Insa Bultmann-Mellin, Maria Guschlbauer, Andreas R. Klatt, Jan Rozman, Martin Klingenspor, Martin Hrabe de Angelis, Jens Alber, Dirk Gründemann, Anja Sterner-Kock, Rudolf J. Wiesner
Format: Article
Language:English
Published: Elsevier 2017-07-01
Series:Molecular Metabolism
Subjects:
Futile cycle
Splanchnic bed
Metformin
Mitochondria
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877817302648

Internet

http://www.sciencedirect.com/science/article/pii/S2212877817302648

Similar Items