CircMAPK1 induces cell pyroptosis in sepsis-induced lung injury by mediating KDM2B mRNA decay to epigenetically regulate WNK1

CircMAPK1 induces cell pyroptosis in sepsis-induced lung injury by mediating KDM2B mRNA decay to epigenetically regulate WNK1

Abstract Background Macrophage pyroptosis is a pivotal inflammatory mechanism in sepsis-induced lung injury, however, the underlying mechanisms remain inadequately elucidated. Methods Lipopolysaccharides (LPS)/adenosine triphosphate (ATP)-stimulated macrophages and cecal ligation and puncture (CLP)-...

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Bibliographic Details
Main Authors: Min Li, Hanjing Lu, Chujun Ruan, Qiao Ke, Longhui Hu, Zhao Li, Xiaoran Liu
Format: Article
Language:English
Published: BMC 2024-09-01
Series:Molecular Medicine
Subjects:
CircMAPK1
Macrophage pyroptosis
Sepsis
KDM2B
WNK1
Online Access:https://doi.org/10.1186/s10020-024-00932-6

Internet

https://doi.org/10.1186/s10020-024-00932-6

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