Treatment of Diet-Induced Obese Rats with CB<sub>2</sub> Agonist AM1241 or CB<sub>2</sub> Antagonist AM630 Reduces Leptin and Alters Thermogenic mRNA in Adipose Tissue

Treatment of Diet-Induced Obese Rats with CB<sub>2</sub> Agonist AM1241 or CB<sub>2</sub> Antagonist AM630 Reduces Leptin and Alters Thermogenic mRNA in Adipose Tissue

Diet-induced obesity (DIO) is a contributor to co-morbidities, resulting in alterations in hormones, lipids, and low-grade inflammation, with the cannabinoid type 2 receptor (CB<sub>2</sub>) contributing to the inflammatory response. The effects of modulating CB<sub>2</sub> w...

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Bibliographic Details
Main Authors: Lannie O’Keefe, Teresa Vu, Anna C. Simcocks, Kayte A. Jenkin, Michael L. Mathai, Andrew J. McAinch, Dana S. Hutchinson, Deanne H. Hryciw
Format: Article
Language:English
Published: MDPI AG 2023-04-01
Series:International Journal of Molecular Sciences
Subjects:
diet-induced obesity (DIO)
inflammation
endocannabinoid system (ECS)
AM1241
AM630
adipose tissue
Online Access:https://www.mdpi.com/1422-0067/24/8/7601

Internet

https://www.mdpi.com/1422-0067/24/8/7601

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